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Page 1
Lipid availability determines fate of skeletal progenitor cells via SOX9.
van Gastel N, Stegen S, Eelen G, Schoors S, Carlier A, Daniëls VW, Baryawno N, Przybylski D, Depypere M, Stiers PJ, Lambrechts D, Van Looveren R, Torrekens S, Sharda A, Agostinis P, Lambrechts D, Maes F, Swinnen JV, Geris L, Van Oosterwyck H, Thienpont B, Carmeliet P, Scadden DT, Carmeliet G. van Gastel N, et al. Among authors: swinnen jv. Nature. 2020 Mar;579(7797):111-117. doi: 10.1038/s41586-020-2050-1. Epub 2020 Feb 26. Nature. 2020. PMID: 32103177 Free PMC article.
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
Meçe O, Houbaert D, Sassano ML, Durré T, Maes H, Schaaf M, More S, Ganne M, García-Caballero M, Borri M, Verhoeven J, Agrawal M, Jacobs K, Bergers G, Blacher S, Ghesquière B, Dewerchin M, Swinnen JV, Vinckier S, Soengas MS, Carmeliet P, Noël A, Agostinis P. Meçe O, et al. Among authors: swinnen jv. Nat Commun. 2022 May 19;13(1):2760. doi: 10.1038/s41467-022-30490-6. Nat Commun. 2022. PMID: 35589749 Free PMC article.
2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.
Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M. Moellmann J, et al. Among authors: swinnen jv. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166825. doi: 10.1016/j.bbadis.2023.166825. Epub 2023 Aug 1. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37536502 Free article.
Lipid degradation promotes prostate cancer cell survival.
Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG. Itkonen HM, et al. Among authors: swinnen jv. Oncotarget. 2017 Jun 13;8(24):38264-38275. doi: 10.18632/oncotarget.16123. Oncotarget. 2017. PMID: 28415728 Free PMC article.
Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption.
Gianfrancesco MA, Dehairs J, L'homme L, Herinckx G, Esser N, Jansen O, Habraken Y, Lassence C, Swinnen JV, Rider MH, Piette J, Paquot N, Legrand-Poels S. Gianfrancesco MA, et al. Among authors: swinnen jv. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1017-1030. doi: 10.1016/j.bbalip.2019.04.001. Epub 2019 Apr 4. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30953761